• Tuesday, 18 October 2022: from 10:00 to 18:00
  • Wednesday, 19 October 2022: from 10:00 to 17:00
  • Adlershof con.vent. Rudower Chaussee 17, 12489 Berlin, Germany.

Academic Talks Free of charge for up to 25 minutes including Q&A
Product Demos Speakers will be charged 580,-€ (VAT excluded) for up to 30 minutes including Q&A

  • There is no submission fee.
  • Proposals must be submitted using the online form. Upon submitting a proposal, you will receive an automatic confirmation for your records if it was submitted successfully.
  • CellME Berlin reserves the sole right to accept or reject any proposal received without liability.
  • CellME Berlin does not pay for a speaking fee. Travel related expenses, meals and ccommodations are the responsibility of the speaker.


  • Complimentary full registration for the conference and exhibition.
  • Abstract book entry at no charge.
  • Free guest tickets to invite audiences.
  • Speaker Certificate in digital format.


Conference language is English.


Last updated: 15 June 2022 | The listing of a proposal does not imply an approval of a presentation. The final programme will be released and can viewed here closer to the event.
The information contained herein is subject to change without prior notice.

One-pot formation and functional monitoring of neural cysts and organoids
Eindhoven University of Technology

Three-dimensional (3D) cell spheroids and organoids have presented a new paradigm for studying the fundamental processes behind organ and tissue regeneration, as well as for developing treatments for diseases, in physiologically relevant 3D tissue contexts. However, robust and reproducible generation of spheroids and organoids remain challenging. In this talk, we will discuss several bioengineering approaches that we have developed to obtain neuroepithelial and neural organoids from human induced pluripotent stem cells in a controlled and tunable manner. The engineering-based approaches allow longitudinal monitoring and characterization, and are also shown to be particularly suitable for basic morphogenesis studies and disease modeling of neurodegeneration.

Modular mini-factories for the autonomous production of ATMPs
Fraunhofer IPA

Personalized medicine, in particular cell and gene therapy, is a relatively new class of therapeutics for which standardized production processes do not yet exist. Current processes for the production of ATMPs are often highly manual, therefore time-consuming and expensive. Consequently, many ATMPs are reserved for only a limited number of patients. To solve these problems, new smart approaches to automation are needed. We are proposing a modular approach where the production of CAR-T cells in a standardized form and with high quality at decentralized facilities should become a reality. In the presentation we would like to introduce you to our solution, the "mini-factory“ and the core elements of the concept: the modular approach, universal interfaces, robotic interlinking and automation of the process under GMP conditions.

Comparison between centralized and decentralized supply chains of autologous chimeric antigen receptor T-cell therapies
University of Oxford

Decentralized, or distributed, manufacturing that takes place close to the point of care has been a manufacturing paradigm of heightened interest within the cell therapy domain because of the product's being living cell material as well as the need for a highly monitored and temperature-controlled supply chain that has the potential to benefit from close proximity between manufacturing and application.

A novel microfluidics based technology: advancing the process development and manufacture cell and gene therapies

MicrofluidX proposes to showcase the end-to-end bioprocessing capabilities of its microfluidics based bioprocessing platform. The results to be presented show the seeding, expansion, transduction/transfection, and harvesting efficiencies that can be achieved on the platform. In addition, there is discussion of MicrofluidX's efforts in the use of PATs to provide valuable and robust data that can inform process control strategies and process monitoring driving real-time, in-line and on-line product and process understanding. Using an exemplar manufacturing process, the cost of goods savings that can be achieved by the platform in comparison to the current best practices are also presented.



Automated Process Control based on in situ measured Glucose concentration in several SUV and SUB
C-CIT Sensors AG

We offer the first process control system for bioproduction based on in situ measurement of glucose and lactate, from smallest vessel to bioreactor scale. Our systems CITSens Bio APC and CITSens MeMo APC make cell line selection easy and fast, allow optimized media & process development and automated media feed. With our solutions sampling is not needed anymore, resulting in reduced contamination risk and cell stress, higher cell density and higher product yields. All our sensors can be adapted to any customized bioreactor. Our systems are suitable for biopharmaceutical as well as for medical applications.

Novel single cell sequencing technologies
Singleron Biotechnologies

High throughput single cell sequencing is enabled by Singleron's cutting-edge technology which allows you to study genes and their functions across tens of thousands of cells simultaneously in a single experiment. It offers you essential insights into the samples with high level of heterogeneity and provide you with crucial information on gene expression across a multitude of cell subtypes present in your sample.The applications that go beyond gene expression profiling are gaining on popularity as well, as they enable you to obtain deeper insights on the function of specific genes by adding additional layers of information, such as for instance temporal resolution, to your data.

Activation and expansion of human T-cells using microfluidic devices

T-cells expressing a chimeric antigen receptor (CAR) are one of the most promising therapeutic modalities for the treatment of hematological malignancies. First, primary T-cell expansion is needed. Then, their activation and proliferation can be better understood if microfluidics is applied as it allows to generate large amounts of data and it is harnessed with image processing to analyze it. One of the major technical hurdles involved in suspension cell culturing is cell immobilization during media renewal. In this work, we use a multilevel microfluidic chip to successfully capture cells. Jurkat and T-cells are isolated through traps to microscopically track their proliferation after activation over a period of 9 days. These multilevel devices provide a new method of studying T-cell activation.

Modular Approach to AI-enabled CAR-T Cell Manufacturing - A Concept for Process Automation

The AIDPATH Project aims to develop a decentralized manufacturing system for CAR-T therapy to be placed in the hospital. The automated platform developed by the Fraunhofer IPT integrates devices for manufacturing CAR-T therapy while em-ploying a closed handling-approach and automated sampling for in-line quality con-trol. AI solutions built into the production process such as a digital twin of the CAR-T product will support the manufacturing process. The presentation will focus on the project and its goals and show the concept for the physical platform. Furthermore, the control software and interfaces to facilitate the automation and the general pro-duction process.

Metabolic-imaging of human glioblastoma explants: a new precision-medicine model to predict tumor treatment response early
Fondazione Pisana per la Scienza

FLIM-based metabolic imaging is used on live glioblastoma 3D explants to test anti-neoplastic drugs. Unlike other models, drug response of live patient-derived tumor explants is performed with no animal involvement and with minimal tampering of natural tumor cyto-architecture, preventing the conventional structural and molecular divergence that the tumor undergoes after long time of in vitro culturing. This novel in vitro approach could be exploited in a range of clinical and laboratory settings to improve patients' clinical management. A method to assess the patient’s tumor specific response to several therapies at an early stage could be transformative for glioblastoma patients’ management. Furthermore, this model can be used for large-scale screening of new pharmaceutical compounds and applied to other cancers.

Precision healthcare supply chain design through multi-objective stochastic programming
Rogel Cancer Center

In this talk, we will addressed key issues in the cyclic supply chain for simultaneous design of the supply chain and the manufacturing plan. A comprehensive optimisation based methodology through both deterministic and stochastic programming is presented to research the Chimeric Antigen Receptor (CAR) T cell therapies. Multiple objectives including maximisation of the overall net present value (NPV) and minimisation of the average response time of all patients are evaluated, while accounting the uncertainties in patients’ demand distribution. Results indicate that the total benefits from the optimized supply chain management are significant compared with the current global market.

CAR-T cell immunotherapy for solid tumors: challenges and future perspectives
Navarrabiomed-Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), Complejo Hospitalario de Navarra (CHN), Instituto de Investigación Sanitaria de Navarra (IdiSNA)

Adoptive cell therapy with genetically modified T lymphocytes that express chimeric antigen receptors is one of the most promising advanced therapies for cancer treatment. However, CAR-T cells efficacy in the solid tumor landscape is still very unsatisfactory. The development of a next generation personalized CAR-T treatment and the identification of therapeutic targets to increase the efficacy, survival, persistence, and safety in solid tumors remains as a clinical necessity and a critical frontier in cancer immunotherapy. Here, we summarize basic, translational and clinical results of the CAR-T cell immunotherapy for solid neoplasms, from its preclinical to its clinical development.

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