Call for Speakers 2024

Day 1: Tuesday, 5 November 2024

9:30

Opening Remarks

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17:00

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Day 2: Wednesday, 6 November 2024

9:30

Opening Remarks

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16:00

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Speaking proposal 2024

Last updated on 17.05.2024. | The listing of a proposal does not imply an approval of a presentation. The final programme will be released here closer to the event.

Comparative analysis of expression of stem cell and EMT markers from the 2D culture and different 3D models of mammospheres; applying a mathematical model

Maria Sklodowska-Curie National Research Institute of Oncology / POLAND

The majority of the current cancer research is based on 2D cell cultures and animal models. These methods have limitations, including different expression of key factors involved in carcinogenesis and metastasis, depending on culture conditions. Addressing these differences is crucial in obtaining physiologically relevant results. Stemness and epithelial-mesenchymal transition (EMT) is linked to the increased invasive potential and metastasis, thus exploring the expression of this markers in a different growth conditions is essential. We report plasticity of expression of selected stem cell and EMT markers in different culture conditions, pointing to the importance of spatial parameters. The most significant difference is the expression of adherent cell junction protein E-cadherin, which changes dramatically between standard 2D culture, floating spheroid culture and matrigel scaffolded culture. As a step towards understanding the reasons causing these discrepancies, we have created a mathematical model of tensions within the 3D bioprinted culture.

Establishment of a Human Lung Organoid Method Platform for Infectious Disease Modelling

Robert-Koch-Institute / GERMANY

In recent years organoids have advanced to prominent and versatile tools in 3R research, representing valuable alternatives for animal testing and physiologically relevant disease models at the same time. As the federal Public Health Institute, the RKI aims to establish an in-house multi-species, multi-organ organoid platform. The objective is a broad methodology in order to strengthen the Institute`s pandemic preparedness plans for novel and re-emerging pathogens, which often have to be handled in a BSL4 laboratory. So far, bronchial and nasal lung organoids have been generated from adult stem cells derived from various primary and commercial cells. Characterisation on mRNA and protein level showed that, with small variances, all organoids consist of a physiologically applicable cell composition.

3D Tumor-like microcapsules: A new personalized strategy to study cancer progression

Heidelberg University / GERMANY

One property characterizing solid tumors, is the mechanical stress. This restricts the cell proliferation, migration and invasion of weakly malignant cells, while stimulating the selection of the most aggressive clones found in a heterogeneous population. Based on this fact, we designed a new kind of artificial tumor- known as Tumor-like microcapsules- which mimic the biomechanical properties sensed by confined cancer cells in vivo. Cells cultured in these matrices show a better, faster, and stronger upregulation of most hallmarks described in neoplastic pathologies, compared to traditional cancer spheroids. Our results have been validated in vitro and in vivo (i.e. zebrafish model, mice), showing that the biomechanical stress is extremely relevant to design new strategies to culture cancer cells in 3D.

Submit your proposal for 2024

Date, time & venue

  • Tuesday, 5 November 2024: from 9:00 to 18:00. / Wednesday, 6 November 2024: from 9:00 to 17:00
  • WISTA Management Conventions. Rudower Chaussee 17, 12489 Berlin, Germany.

Fees

  • Academic talks: Free of charge for up to 25 minutes including Q&A.
  • Product Demos: Speakers will be charged 880,-€ (VAT excluded) for up to 30 minutes including Q&A.
  • There is no submission fee.

Format

    • All oral presentations are in-person only. There is no virtual or hybrid option for attendees.
    • There will be no poster sessions.

    Language

    The conference language is English.

    Submission deadline

      There is no set deadline to submit a speaking proposal until all open slots are filled.